Improvement of Gene-Edited Immune Cell Manufacturing for Clinical Trials

We are collaborating with multiple labs at UCSF to establish a gene-edited immune cell clinical platform
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As immunotherapeutic strategies move toward more complex engineering and multiplexed editing, there is a growing need to optimize the manufacturing of CAR-engineered cells for the clinic. Our laboratory is focused on bolstering the efficiency of CAR T cell enrichment, improving the precision of T cell editing using novel tools developed in the lab. Finally, we are expanding our technologies to other immune cells and are optimizing gene editing protocols and CAR designs for NK cells.

HELLO

Selected Publications

Spatially organized multicellular immune hubs in human colorectal cancer
Pelka K, Hofree M, Chen JH, et al. Spatially organized multicellular immune hubs in human colorectal cancer. Cell. 2021

News

Media highlights of Pelka Lab's research.
Juggling Motherhood and Science
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Cancer Immunologist Karin Pelka Joins Gladstone Institutes
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Researchers discover immune cell “hubs” hiding in tumors
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SU2C Peggy Prescott Early Career Scientist Award in Colorectal Cancer Research
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Stand Up to Cancer Awards $1.1 Million in Grants to Research Teams
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Faith Fight Finish Foundation Gala
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‘Goodness, I’m getting emotional’: How Cowboys QB Dak Prescott brought Jerry Jones to tears at gala
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Stand Up to Cancer Grants First Peggy Prescott Award in Colorectal Cancer Research
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